【摘要】 本工作研究Batroxobin对狗心脏I/R损伤过程中ET水平的影响。将狗左冠状动脉前降支结扎 30min ,恢复血流 90min ,造成I/R模型 ,于缺血前或缺血后 15min静注Batroxobin (1U/kg) ,测定血浆、心肌ET浓度以及血浆CK和LDH活性。结果表明 ,I/R组心肌组织及血浆ET水平明显升高 ,心肌组织明显损伤 ,Batroxobin能够显著降低再灌期血浆及心肌ET水平 ,降低CK及LDH活性 ,减轻心肌组织I/R损伤。更多还原

【Abstract】 The effect of batroxobin on endothelin(ET)level in canine heart ischemia/reperfusion (I/R) injury was investigated Canine heart ischemia was induced by ligation of the left anterior descending coronary artery for 30 min followed by 90 min reperfusion.Batroxobin was intravenously administered before heart ischemia and 15 min before reperfusion.The concentration of both plasma and myocardial endothelin (ET) was measured, and the activities of creatine phosphokinase (CK) and lactic dehydrogenase (LDH ) were also measured The results showed that ET levels of both plasma and myocardium in I/R group increased significantly,and myocardium was injured obviously Batroxobin can reduce ET in plasma and myocardium , and can reduce the activities of CK and LDH In addition, it can alleviate the myocardial injury of ischemia /reperfusion更多还原