【摘要】 目的探讨高盐饮食对自发性高血压卒中倾向鼠(SHRSP)血浆组织因子途径抑制物(TFPI)活性的影响。方法 16只22周龄SHRSP随机分为对照组和高盐饮食组。分别在分组喂养前、26、30周龄采尾血。TFPI活性用美国Diagnostica Inc.Acticchrome TFPI活性测定试剂盒(ADI980330)测定。结果 高盐喂养组和对照组在第26、30周龄时测得血浆TFPI活性分别为(1.52±0.12)、(1.29±0.10)、(1.17±0.17)U/ml和(1.53±0.10)、(1.56±0.09)、(1.65±0.13)U/ml。多组间t检验显示高盐组于26、30周龄时血浆TFPI活性明显低于22周龄时和对照组各采血点;对照组随周龄增加TFPI活性升高。结论高盐饮食可明显降低SHRSP血浆TFPI活性。更多还原

【Abstract】 Objective To investigate whether tissue factor pathway inhibitor (TFPI) activity is influenced by high sodium loading in spontaneously hypertension stroke-prone (SHRSP) rats . Methods TFPI activities were investigated in SHRSP rats (n= 16). The rats at the age of 22 weeks were divided into 2 groups, the control group (n = 8) and high sodium loading group(n=8). Blood samples were drawn before examination and at the age of 26, 30 weeks. TFPI activities were determined with Diagnos-tica Inc. Acticchrome TFPI activity kit. Results TFPI activities of two groups at deferent times were (1. 52 + 0.12), (1.29 +0.10), (1.17 + 0. 17) U/ml and (1. 53 + 0. 10), (1. 56 + 0. 09), (1. 65 + 0.13)U/ml. The activities were significantly lower in the high sodium loading group than that in the control group after 4 weeks of high sodium loading. TFPI activities at the age of 26 weeks and 30 weeks were higher than that at the age of 22weeks, showing positive correlation with the age. Conclusions Sodium loading decreases TFPI plasma activities in spontaneous hypertension stroke-prone rats.更多还原