【摘要】 方酸与不同烃基结构的醇反应生成相应的方酸二酯 ,继而与手性氨基醇作用合成了方酸C-3位含酯氧基的手性方酰氨基醇配体 .手性方酰胺正丁脂经水解或与硫氢化钠作用分别得到 C-3位含羟基和巯基的手性方酰氨基醇配体 .上述新型配体与硼烷作用形成的手性口恶唑硼烷可用于前手性酮的不对称催化还原反应 .所有新型配体的结构已被 IR,1 H NMR,MS和元素分析所确证 .更多还原

【Abstract】 A varieties of squaric acid diesters are prepared by the reactions of squaric acid and correspording alcohols with different alkanes. Follow them, by the reaction with (1S,2R)-(+)- or (1R,2S)-(-)-2-amino-1,2-diphenylalcohol, the C-3 chiral squaric acid amidoalcohols with alkoxyl are synthesized. The chiral squaric acid amidobutyl ester can be hydrolysis or reacted with NaHS to form the C-3 squaric acid amidoalcohols of with OH or SH respectively. The chiral oxazaborolidines that formed by the reaction of the new ligands above with borane can be used in the asymmetry catalytic reaction prochiral ketones. The structures of all the new ligands are affirmed by IR, 1 H NMR, MS and elemental analysis.更多还原