【摘要】 目的　探讨氨及分泌性免疫球蛋白A(sIgA)在幽门螺杆菌 (Helicobacterpylori,HP)导致慢性浅表性胃炎中的作用。方法　选取慢性浅表性胃炎患者 6 3例 ,按组织学分型分为轻、中、重度胃炎 ,按有无中性粒细胞的出现分为活动性和非活动性胃炎 ;胃液氨的测定采用氨试剂盒 ,sIgA的测定采用放射免疫法 ,HP检出采用尿素酶试验及Warthin Starry染色。结果　慢性浅表性胃炎患者幽门螺杆菌检出率为 49.2 1%。HP阳性胃炎患者中胃液氨浓度及sIgA浓度明显高于HP阴性者 ,差异极显著 (P <0 .0 0 1)。HP阳性活动性胃炎患者胃液氨与HP阳性非活动性胃炎患者胃液氨无差异 (P >0 .0 5 )。而HP阳性活动性胃炎患者胃液sIgA明显高于HP阳性非活动性胃炎患者 (P <0 .0 5 )。轻度胃炎胃液氨明显低于重度者 ,差异显著 (P <0 .0 5 )。轻度胃炎sIgA明显低于中、重度者 ,差异极显著 (P<0 .0 0 1)。结论　HP是慢性浅表性胃炎的致病因素之一 ,其致病机制与HP产生的氨的损伤作用以及sIgA保护作用降低有密切关系。更多还原

【Abstract】 Objective To investigate the role of ammonia and sIgA in chronic superficial gastritis induced by Helicobacter pylori(HP).Methods 63 patients with chronic superficial gastritis were divided into slight,mild,severe gastritis and active,non active gastritis.The ammonia and sIgA levels of gastric juice were measured.Results HP was found in 31 cases among 63 patients with chronic superficial gastritis(49.21%).The average concentration of ammonia and sIgA in HP positive patients were higher than that of HP negative patients ( P <0.001). Ammonia in gastric juice in HP positive patients with active gastritis had no difference with that in HP positive patients with non active gastritis( P >0.05);but sIgA in HP positive patients with active gastritis was higher than that in HP positive with non active gastritis patients( P <0.05). Ammonia in slight gastritis were lower than that in severe gastritis( P <0.05);sIgA level in slight gastritis were lower than that in mild,high gastritis( P <0.05).Conclusion That ammonia and sIgA might play an important role in the pathogenesis of HP positive gastritis.更多还原