【摘要】 目的 :观察生脉注射液对阻塞性黄疸 (阻黄 )术后炎症介质及肾功能的作用。方法 :阻黄及非黄疸的肝胆外科患者分成三组 ,术后给予一般治疗阻黄 (OJ)组、非黄疸 (NON OJ)组及生脉注射液治疗阻黄组。动态观察血浆炎症介质内毒素 (LPs)、肿瘤坏死因子 (TNF α)、白细胞介素 6 ,8(IL 6 ,IL 8)、内皮素 (ET)以及肾脏功能指标尿转铁蛋白 (TFR)、尿白蛋白 (ALB)及尿视黄醇 (RBP)的变化。结果 :生脉注射液治疗组术后 7天与术后 1天相比 ,LPs、IL 6、IL 8、ET、TNF α、TFR、RBP、ALB明显下降 (P <0 0 5〉 ,且低于或接近术前水平 ,黄疸对照组在术后 7天与术后 1天相比无显著差异 (P >0 0 5 )。结论 :生脉注射液对阻黄患者术后LPs有拮抗作用 ,同时降低其它炎症介质水平 ,另外还具有保护肾脏功能的作用。更多还原

【Abstract】 OBJECTIVE:To investigate the effect of Shengmai injection on inflammatory mediator and renal injury in obstructive jaundice METHODS:The patients with obstructive jaundice were randomly divided into 2 groups 15 cases of non jaundiced patients as another control group according to preoperative arrangement The plasma ET, LPs, TNF а, IL-6, IL 8 and urine RBP, TFR, ALB were measured pre and post operative 1, 4, 7 days RESULTS:LPs , TNF а, IL 6, IL 8, ET, RBP, TFR and ALB level of Shengmai injection group during post operative 7 day were obviously lowered as compared with the same group during post operative 1 day( P <0 05) CONCLUSION:post operative uses of Shengmai injection might effectively decrease the post operative level of plasma LPs, ET, TNF α and IL 6,IL 8 At the mean time, Shengmai injection may protect renal function by inhibiting inflammatory mediator and improving blood dynamics更多还原