【摘要】 目的　研究机械性创伤患者伤后血清肿瘤特异性生长因子 (TSGF)的变化及其与创伤评分的关系 ,探讨发生原因及临床意义。方法　将 5 0例机械性创伤患者按创伤评分标准分成三组 ,轻度 31例 ,ISS≤ 16 ;重度 13例 ,16 <ISS<2 5 ;极重度 6例 ,ISS≥ 2 5 ,全部患者于伤后 2 4小时内采血 ,其中 2 5例还于 3、5、7、9、12天各采血 1次。结果　创伤后 2 4小时内各组 TSGF明显高于正常值 (P<0 .0 5 ) ,三组患者血清 TSGF呈波动性先升后降的变化 ,高峰值均出现于 7天 ,TSGF于 5 ,7,9,12天时极重度和重度 >轻度 (P<0 .0 5 )。结论　 TSGF可能与炎症反应和创伤修复有关。更多还原

【Abstract】 Objective To investigate the post traumatic changes in the serum level of tumor specific growth factor(TSGF) and their relationship with Injury Severity Score and to inquire into the possible mechanism and clincal significance. Methods Fifty patients with mechanical trauma were eligible and included. According to the standard of Injury Severity Score (ISS), the patients were divided into there groups: mild degree group,(ISS≤16, n =31) severe degreegroup (16<ISS<25, n =13) extreme severe degree group (ISS≥25, n =6). The blood samples of all patients were obtained within 24 hours, and those of 25 dynamiclly observed patients were obtained on days 3,5,7,9 and 12. Results The serum level of TSGF was significantly higher in patients with trauma in different groups ( P <0.05). The dynamical observation showed that the index demonstrated curve changes with increase in early stage and decrease later. the climax of TSGF appeared on 7 day in all 3 groups.The TSGF serum levels in extremely severe degree and severe degree groups>mild degree group on days 5,7,9 and 12 day ( P <0 05). Conclusion TSGF has relationship with the inflammatory response and recovery of trauma.更多还原