【摘要】 目的　观察我院制备的氯洁霉素水溶性栓剂对治疗细菌性阴道病的疗效。方法　对 1998年 9月至 1999年 1月在我院门诊就诊的阴道感染妇女进行细菌性阴道病的筛选诊断 ,并将符合诊断的 80例患者通过随机分组分别应用甲硝唑栓剂和我院药剂科制备的氯洁霉素栓剂治疗该病。结果　甲硝唑组的治愈率为 87.5 % ,氯洁霉素组的治愈率为 90 .3% ,两组无显著性差异 (P>0 .0 5 )。氯洁霉素对阴道粘膜和外阴无刺激性 ,溶解时间短 ,无一例因药物刺激而停止用药。结论　本制剂对治疗细菌性阴道病具有良好的疗效且无刺激性 ,可作为该病的临床治疗用药更多还原

【Abstract】 Objective To make the soluble suppository of clindamycin which is an effective drug for treament of Bacterial vaginosis and to treat patients in clinical trials.Methods Outpatients who had vaginal infections from Sept.1998 to Jan.1999 were investigated.The diagnoses of bacterial vaginosis were made according to Amsel’s criteria and 80 patients were included in this study. They were divided into two groups to be treated respectively by metronidanole suppository and clindamycin suppository which were made by our hospital pharmacy. Results The cure rate of metronidanole was 87.5% and that of clindamycin 90.3%; No significant difference was noted between the two groups( P >0 05). The new clindamycin suppository was not irritant and it was easy to dissolve in vagina. There was no discontinued treatment because of side effect. Conclusion The clindamycin suppository does not irritate the mucosa of vagina,it is an efficacious remedy for bacterial vaginosis.更多还原