【摘要】 通过改进的 Phillips方法用 L( +) -酒石酸、L( +) -谷氨酸及 L( +) -天冬氨酸与邻苯二胺以盐酸盐形式在乙二醇中反应 ,合成了 3种手性双苯并咪唑化合物 ( 1 R,2 R) -二 ( 2 -苯并咪唑 )乙二醇 ( Hbb Imed) ;( 1 S) ,3-二 ( 2 -苯并咪唑 ) -1 -丙胺( bb Impa) ,( 1 S) ,2 -二 ( 2 -苯并咪唑 )乙胺 ( bb Imea) ;反应产率比文献方法提高。还用 KBH4分别测定了各手性化合物对苯乙酮和丁酮的不对称氢化反应性能更多还原

【Abstract】 Three chiral bibenzimidazole compounds( 1R,2R ) bis (1 H benzoimidazol 2 yl)ethane 1,2 diol(HbbImed),(1 S ),3 bis (1 H benzoimidazol 2 yl)propylamine(bbImpa)and (1 S ),2 bis (1 H benzoimidazol 2 yl)ethylamine(bbImea)were synthesized by an improved Phillps method through the reaction of L (+) tartaric acid, L (+) glutamic acid and L (+) aspartic acid with o phenylenediamine in ethylene glycol in different hydrochloride forms,and the chemical yield is increased compared with the literature method The asymmetric hydrogenation ability of these compounds was measured by reduction of PhCOCH 3 and CH 3COCH 2CH 3 with KBH 4更多还原