【摘要】 以价廉的季铵盐 A-1为相转移催化剂 ,无水 K2 CO3 为碱 ,在无溶剂条件下研究了丙二酸二乙酯与正溴丁烷及其他中长碳链卤代烃的烃基化反应。反应物摩尔比为 n(CH2 (CO2 Et) 2 )∶ n(RX)∶ n(K2 CO3 )∶ n(A-1 ) =1∶ 1 .2∶ 1 .3∶0 .0 3 ,回流反应 2 h,产率均在 90 %以上。更多还原

【Abstract】 Alkylation of diethyl malonate with n butyl bromide and other alkyl halide possessing moderate and long carbon chain was investigated in the absence of solvent.In the reaction,cheap quaternary ammonium salt A 1 was used as phase transfer catalyst and anhydrous K 2CO 3 was used as base.The molar ratio of diethyl malonate∶alkylhalide∶K 2CO 3∶A 1 is 1∶1.2∶ 1.3 ∶0.03 and the reflux time for the reaction is 2h.Under these conditions the yields are all above 90%.更多还原