【摘要】 目的　探讨七宝美髯丹对老龄小鼠 (1 5月龄 )乳头体神经元超微结构的影响 ,为中药抗衰益智的复方对乳头体神经元的干预作用提供形态学资料。方法　电镜形态学观察。结果　与老年组比较 ,七宝美髯丹组神经元脂褐素含量减少 ,细胞膜、核膜及线粒体结构清晰 ,含丰富的核糖体与粗面内质网。老年对照组粗面内质网脱颗粒 ,胞浆聚集 ,脂褐素电子密度增大 ,核糖体与粗面内质网减少 ,神经元与线粒体平均密度降低 ,线粒体平均体积明显增加且肿胀 ,甚至空泡化。推测线粒体在衰老退行性变时 ,其代偿机制可能发挥重要作用。结论　衰老能引起老龄小鼠乳头体超微结构异常 ,七宝美髯丹对此有一定的防治作用更多还原

【Abstract】 To explore the effects of Qibaomeirandan on the ultrastructural changes of the neurons in the mammillary body area in aged(15-month) mice.Methods:morphocy tologic changes in the mammillary body area were observed by electron microscopy.Results: The contents of lipofuscin in the neurosn of the region in the experiment group were reduced as compared with that of the old group.In the Qibaomeirandan treatment group,the normal membranes and the structures of the mitochondria were clearly seen in the hippocampus neurons in the mice;the ridges of the mitochondrion could clearly be seen,with rich rough endoplasmic reticula and ribosomes,and a large amount of clear synaptic vesicles could be seen also.The aged controls showed depolymerization of ribosomes,accumulation of lipid droplets and lipofuscin in cytoplasm,and condensation of chromatin.In the meantime,the average density of the neurons in the mammillary body area became shrunk with the aging under the electron microscopy,and the decrease in the number of ribosome and rough endoplasmic reticula was in the same condition as well.Obviously increased average volume of the mitochondra with swelling,even vacuolization,was observed.It is presumed that the compensatory mechanism may play an important role in the mitochondrion degeneration with aging.Conclusion: Aging can cause microstructure abnormalities of the mammillary body in mice and Qibaomeirandan prevent this abnormal structure formation.更多还原