【摘要】 目的 :探讨染色体核型改变与骨髓增生异常综合征的关系及对预后影响。方法 :采用直接法、短期培养法和R显带技术制备染色体 ,根据复杂分类法进行染色体核型分析。结果 :87例标本中 ,70例出现染色体核型异常 ,检出率为 80 46 % ,核型异常包括数目异常 (超二倍体及亚二倍体 )和结构异常 (结构重排和易位 )。其中有 16例转化为白血病 ,转化率为 18 39%。结论 :染色体核型异常与临床分型无明显的相关性 ,但可能与骨髓增生异常综合征向白血病转化有关更多还原

【Abstract】 Aim: To explore the relationship between chromosome abnormalities and myelodysplastic syndrome,and the influence of chromosome abnormalities on the prognosis of myelodysplastic syndromeMethods:The chromosome were prepared with direct method,brief culture of cells and R-banding techniques,and the karyotypic analysis was performed on the base of complex classificationResults:Seventy out of 87 patients(8046%)had karyotypic abnormalities,which included the numberal abnormalities of chromosomes (ultrodiploid and subdiploid,respectively)and structural alterations(rearrangement and translocation)Sixteen out of 87 patients with chromosomal defects developed into leukemia(18.39%)Conclusion:There is no significant relationship between the karyotypic abnormalities and the clinic classification,but a possibility of the transformation of leukemia from myelodysplastic syndrome may be present.更多还原