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流式细胞术在人急性白血病免疫分型中的应用

Flow cytometry used in the immunophenotype in adult acute leukemia

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【Author】 ZOU Dianbin 1) ,GUO Rong 2) ,ZHANG Qiutang 1) ,WEI Guoqing 2) ,HE Fei 2) 1)Department of Hematology,the First Affiliated Hospital,Henan Medical University,Zhengzhou 450052 2)Postgraduate,Henan Mechical University,Zhengzhou 450052

【机构】河南医科大学第一附属医院血液科!郑州450052；河南医科大学研究生!郑州450052；

【摘要】目的 :研究流式细胞仪 (Flowcytometry,FCM)检测急性白血病 (AL)细胞表面抗原的方法及临床意义。方法 :以FCM为基础 ,应用一组三色荧光标记单克隆抗体 (Monocolonalantibody,MoAb)对 14例AL患者进行免疫分型。结果 :5例为双表型 ,即同时表达二系抗原 (急性髓细胞白血病 (AML) 3例 ,急性淋巴细胞白血病 (ALL) 2例 ) ;9例为系列专一性 (即仅表达一系抗原 ,AML 6例 ,ALL 3例 )。结论 :双表型较系列专一型预后差 ;FCM法具有测定细胞量大 ,快速和准确的优点 ,值得推广应用更多还原

【Abstract】 Aim:To study antigen expression characteristic of acute leukemia(AL) immunophenotype by FCM and clinical significance.Methods: Fourteen patients with AL were investigated with MoAb and immunofluorescence.Results: Five cases were characteristic of double lineage expression,namely two lineage antigen expression simultaneously(AML 3 cases,ALL 2 cases);9 cases were characteristic of one lineage expression(AML 5 cases,ALL 4 cases).Conclusion: ALL with double lineage expression is related to poor prognosis;FCM have a characteristic of detecting large quantity of cells,rapidness and accuracy.更多还原

【关键词】白血病；急性；免疫分型；双表型；流式细胞术；
【Key words】 Leukemia,acute； Immunophenotype； double lineage expression； flow cytometry；

【文献出处】河南医科大学学报 ,Journa of Henan Medical University , 编辑部邮箱 ,2001年01期

【分类号】R733.71
【被引频次】12
【下载频次】102

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