【摘要】 目的 :研究急性酒精中毒对兔脑外伤后的影响。方法 :家兔 30只 ,随机分为 3组 ,每组 10只。A组为正常对照组 ,B组为单纯脑外伤组 ,C组为酒精中毒加脑外伤组。乙醇灌胃法致使家兔急性酒精中毒 ,直接打击颅骨法制作急性颅脑损伤模型 ;于伤前、伤后一定时间测定呼吸频率、平均动脉压、颅内压、大脑中动脉血流速度(vmca)、脉搏指数 (PI)、脑血管直径指数 (CVI) ;伤后 4h处死动物 ,测定脑组织超氧化物歧化酶 (SOD)活性、脂质过氧化物 (LPO)含量及含水量。结果 :C组伤后立即出现显著的呼吸抑制及低血压 ,vmca明显减慢 ,PI值显著升高 ,CVI明显减小 ,伤后 4hSOD活性明显降低 ,LPO含量及脑含水量明显增高 (P <0 0 1)。结论 :伤前醉酒可使兔脑外伤后发生显著的呼吸抑制、低血压、脑血管收缩及脑末梢血管阻力增加 ,使脑血流量 (CBF)显著减少 ,并加重脑外伤后自由基反应 ,加重脑水肿更多还原

【Abstract】 Aim: To study the influence of acute alcohol intoxication on rabbits with head injury.Methods: 30 rabbits were divided into three groups,ten in each one.Group A was nomal control group;group B was head injuried group;group C was alcohol intoxicated and head injuried group.Acute alcolhol intoxication of rabbits were made by gastric administration of ethanol nd head injury by free drop hammer hitting skull.The changes of respiratory rate (RR),mean aterial blood pressure (MABP),intracranial pressure(ICP),middle cerebral artery flow velocity ( v mca )、pulsatility index(PI) and cerebral vesscular diameter index(CVI) were mearsured at different moments before and after head injury. SOD activities、LPO contents and water content in brain were detected at 4 h after head injury.Results: The marked depression of respiratory,lower MABP,slower v mca ,higher PI,less CVI,lower SOD,higher LPO and water content ( P >0.01) were observed in alcohol intoxicated head injuried rabbits. Conclusion: Alcohol intoxication can result in significant respiratory depression,hypotension,cerebral vasospasm,and increase in resistance of cerebral blood vessels,decrease in CBF,promoted free radical reactions and exacerbated brain edema following head injury.更多还原