【摘要】 目的 :探讨乳腺癌患者腋窝淋巴结转移与骨转移之间的关系。方法 :所有患者手术时均接受同侧腋窝淋巴结清扫术 ,并对淋巴结进行病理检查 ,所有患者术后定期接受单光子发射型计算机断层 (SPECT)全身骨显像。结果 :2 92例乳腺癌患者中低分化癌骨转移率为 2 7 3% (6 / 2 2 ) ,高分化癌骨转移率为 45 2 % (12 2 / 2 70 ) ,两者差异无显著性 (P >0 .1) ;有腋窝淋巴结转移的患者骨转移率为 5 4 3% (10 0 / 184) ,无腋窝淋巴结转移的患者骨转移率为 2 5 9%(2 8/ 10 8) ,两者差异有显著性 (P <0 .0 0 1) ;有腋窝淋巴结转移的患者 2年内和 2年以上骨转移率分别为 48 4% (6 2 /12 8)和 6 7 8% (38/ 5 6 ) ,两者差异有显著性 (P <0 .0 2 5 ) ;无腋窝淋巴结转移的患者 2年内和 2年以上骨转移率分别为2 4 2 % (16 / 6 6 )和 2 8 6 % (12 / 42 ) ,两者差异无显著性 (P >0 .5 )。结论 :乳腺癌患者骨转移与乳癌的高低分化程度无关 ;有腋窝淋巴结转移的患者骨转移率增高 ,且随时间增多更多还原

【Abstract】 Objective To investigate the relationship between the axially lymph nodes metastases and the bone metastases in patients with the breast cancer. Methods Lymphadenotomy of the axially lymph nodes had been performed on patients with the breast cancer, and the excised axially lymph nodes were observed by pathological examination. All patients underwent postoperatively total bone scan with single photon emission computer tomography (SPECT) periodically. Results Among 292 patients with the breast cancer, the bone metastatic rates of low and high differentiating tumor were 27.3% (6/22) and 45.2%(122/272) respectively, the bone metastatic rates in both tumors had no difference (P>0.1). The bone metastatic rate was 54.3% (100/184) in patients suffered from the axially lymph nodes metastases, and 25.9% (28/108) in non metastases patients respectively, the difference of their bone metastatic rates was significant (P<0.001). The bone metastatic rate was 48.4%(62/128) in patients suffered from the metastases of axially lymph nodes after operation less 2 years, and 67.8% (38/56) after operation more than 2 years respectively, the difference of their bone metastatic rates was not significant (P>0.5). Conclusions There is no relationship between the bone matastatic rates and the pathological type of tumor. The bone metastatic rates of patients with the axially lymph nodes metastases are higher than those with non metastases of axially lymph nodes. In addition, the bone metastatic rates of patients with the axially lymph nodes metastases increase with time prolongation.更多还原