【摘要】 目的探讨六价格对小鼠外周血丙二醛含量 (MDA)与小鼠外周血嗜多染红细胞 (PCE)微核率的影响。方法选择昆明种小鼠60只 ,随机分为6组 ,每组6只 ,分别以10.27、13.83、20.74、41.48mg/kg铬酸钙灌胃染毒 ,每日1次 ,连续6天。阴性对照为蒸馏水 ,阳性对照为环磷酰胺 (40mg/kg) ,进行小鼠外周血MDA与微核率的测定。结果随着六价铬剂量的增加 ,MDA的含量和微核率均上升。微核率 (x)与MDA(nmol/ml)的含量 (y)呈正相关 (y=3.705 +930x,r=0.958,P<0.05)。结论六价铬能促进脂质过氧化和PCE中微核发生更多还原

【Abstract】 Objectiv To explore the effects of chromium (Ⅵ) on the levels of malondialdehyde (MDA), the final product of lipid peroxidation in peripheral blood of mice and the micronucleus rate of polychromatic erythrocytes (PCE) in peripheral blood. Method 60 Kunming mice were divided randomly into 6 groups averagely. 4 groups were selected as exposure groups which were exposed to 10.27, 13.83, 20.74, 41.48 mg/kg calcium chromate by oral perfusion, one time per day, for 6 days. The negative and positive control group was exposed to distilled water and cyclophos phamide (40 mg/kg) respectively. After exposure, the levels of MDA and micronucleus rates of PCE were determined. Results Significant increases of the levels of MDA and the micronucleus rates of PCE in peripheral blood of mice were observed, which were associated with the increases of the exposure doses of chromium (Ⅵ). Significant positive correlation was observed between the micronucleus rates of PCEs (x) and MDA(nmol/ml) levels (y) in peripheral blood (y=3.705+930x,r=0.958, P<0.05) Conclusion Chromium (Ⅵ) could promote the lipid peroxidation and the increase of micronucleus in PCEs in peripheral blood of mice.更多还原