【摘要】 目的　观察亚硒酸钠和维生素 E对烹饪油烟凝集物 (COF)致突变的拮抗作用。方法　在经过 COF处理的人外周血淋巴细胞培养物中注入一定剂量的亚硒酸钠或一定剂量的维生素 E来观察淋巴细胞的姊妹染色单体交换 (SCE)率。结果　经过 37℃ 4 h温育的亚硒酸钠可显著降低 COF处理过的淋巴细胞 SCE率 ;终浓度分别为 0 .9× 10 - 7mol/ L的亚硒酸钠和 5 μl维生素 E在降低 COF处理过的淋巴细胞 SCE率方面存在着极显著的协同效应。结论　经过 4 h温育的一定剂量的亚硒酸钠和维生素 E在拮抗 COF的致突变性过程中存在着极显著的协同效应 ;亚硒酸钠单因素亦存在一定的拮抗作用更多还原

【Abstract】 Objective To observe the antimutagenic action of sodium selenite and vitamin E on condensates of cooking oil fumes(COF) Methods SCE (sister chromatid exchanges) were observed and contrasted before and after addition of sodium selenite or vitamin E at a certain dose to the culture of human peripheral blood lymphocytes treated by COF Results Sodium selenite added to lymphocytic culture treated by COF at 37 ℃ for 4 hour incubation significantly lowered the frequencies SCEs of lymphocytes and very significant synergistic effects on lowering frequencies of SCEs were observed during adding both sodium selenite(terminal concentration 0 9×10 -7 mol/L) and vitamin E(torminal concentration 0 1% (v/v) to lymphocytic culture treated ty COF for 4 hour incubation Conclusion Combined sodium selenite and vitamin E at certain concentrations in cultured lymphocytes for 4 hour incubation showed very significant synergistic effects on lowering the mutagenicity of lymphocytes induced ty COF.Sodium selenite alone was also shown to be effective in lowering the frequencies of SCEs of human peripheral blood lymphocytes更多还原