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188Re诱发人离体外周血淋巴细胞染色体畸变的初步研究

Study on chromosome aberration in human peripheral blood lymphocytes induced by 188ReO4- in vitro

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【作者】 董墨李惠源吴元芳邵松生林雅萍邹美君刘红珍

【Author】 DONG Mo LI Huiyuan WU Yuanfang (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800) SHAO Songsheng LIN Yaping ZOU Meijun LIU Hongzhen (Institute of Radiation Medicine, Shanghai Medical University, Shanghai 200

【机构】 中国科学院上海原子核研究所上海市放射医学研究所上海市放射医学研究所 上海201800上海201800上海200032上海200032

【摘要】 将人离体外周血在不同剂量的188ReO- 4中培养 5 4h ,观察淋巴细胞有丝分裂中期的染色体型和单体型畸变 ,这两种类型的畸变均有随188Re活度的增高而增加的趋势 ,并与活度存在一定的依赖关系 ,染色体畸变以二次多项式的模式为佳。单体型畸变、畸变细胞、染色体断片也可配以直线回归。

【Abstract】 Human peripheral blood exposed to 188 ReO - 4 at various doses for 54h was examined to observe the chromosome and chromatin aberrations at metaphases during mitosis of lymphocytes. The findings indicate that there was a tendency of increased aberration in both types with increasing 188 ReO - 4 concentration and a dose dependency can be seen. The aberration yield is best fitted by the quadratic model. Chromatin aberrations, aberrations cell and chromosome fragments are also fitted by a linear-regression model.

【关键词】 188ReO4外周血染色体畸变
【Key words】 ReO - 4Peripheral bloodChromosome aberration
  • 【分类号】R818
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