【摘要】 目的　研究胃肠道间质瘤的临床病理特征。方法　观察分析 2 0例胃肠道间质瘤的临床病理特征 ,采用免疫组化染色。结果　镜下由梭形细胞和上皮样细胞组成或以其中一种为主。免疫组化为四个亚型 :平滑肌型 5 5 % ,Desmin阳性 ;神经源型 5 % ,S 10 0阳性 ;双向分化型 15 % ,Desmin和S 10 0均阳性 ;未分化型 2 5 % ,Vimentin和CD34 阳性 ,后二型肿瘤性质为交界性或恶性。结论　胃肠道间质瘤是具有一系列临床病理特征的独立肿瘤 ,具有多种免疫表型 ,肿瘤的性质与分化表型有一定关系更多还原

【Abstract】 Objective To analyze the clinicopathologic features of gastrointestinal stromal tumors(GIST).Methods The clinicopathologic features of 20 cases of GIST were studied and immunohistochemical analyses were made.Results Tumors were composed of spindle cells and epithelioid cells,or predominantly composed of either one.The neoplasms were classified as four types:55% smooth muscle differentiated tumors(type Ⅰ),Desmin being positive;5% neurogenic differentiated tumors(type Ⅱ),S 100 being positive;15% mixed smooth muscle cell and neurogenic differentiated tumors (type Ⅲ),both Desmin and S 100 being positive;25% undifferentiated GIST(typeⅣ),the immunophenotype of which was vimentin and CD 34 .Types Ⅲ and Ⅳ were intermediate or malignant.Conclusions GIST are the tumors with unique clinicopathologic features and heterogeneous immunophenotype.The behavior of the tumor is related to its differentiated type in some degrees.更多还原