【摘要】 目的　本文观察了羟基喜树碱 (HCPT)、氨甲蝶呤 (MTX)、5 氟脲嘧啶 (5 Fu)和醛氢叶酸钙(LV)联合方案治疗晚期肺腺癌的疗效及毒副作用。方法　化疗方案为羟基喜树碱 8mg m2 静脉滴注 ,第 1～ 5天 ;氨甲蝶呤 10 0mg静脉推注 ,第 1日 ;醛氢叶酸钙 15 0mg m2 第 2～ 4天 ,静脉滴注 ;5 氟脲嘧啶5 0 0mg m2 静脉滴注 ,第 1～ 5天 ;2 8d为 1周期 ,连用 2个周期以上。结果　HMLF方案治疗晚期肺腺癌5 1例 ,总有效率 49% ,1年生存率 41% ,中位生存期为 11个月。主要毒副作用为轻度的血液和消化道反应。结论　羟基喜树碱为主的HMLF方案是治疗晚期肺腺癌有效且毒性较小的联合化疗方案更多还原

【Abstract】 Objective The therapeutic effects and side effects of combined chemotherapy of HCPT, MTX, LV and 5 Fu for Advanced Lung adenocarcinoma were evaluated.Methods Chemotherapy regimen consisted of HCPT 8 mg/m 2 IV gtt l～5 d, MTX 100 mg IV dl, and Leucovorin 150 mg/m 2 IV gtt 2～4 d, 5 Fu 500 mg/m 2 IV gtt 1～5 d. The cycle was repeated every 4 weeks and 2 cycles were given as 1 course.Results Total 51 cases was treated. Overall CR+PR was 49% .One year survival rate was 41%, Main median survival interval was 11 months. The major side effects were bone marrow suppression and gastrointestinal tract side effects.Conclusion The combined chemotherapy regimen consisting of HCPT was benefit for advanced lung adenocarcinoma.更多还原