【摘要】 目的探讨降纤酶治疗不稳定型心绞痛（ＵＡＰ）的疗效。方法将３８例新近发生的静息性心绞痛持续时间＞１５ｍｉｎ的患者随机分组：Ａ组（１８例）给予口服阿司匹林（１００ｍｇ／ｄ）和抗心绞痛药物； Ｂ组（２０例）给予阿司匹林和抗心绞痛药物加静滴降纤酶（ １０ｕ加入生理盐水 １００ｍｌ中滴注，连续 ７天）。结果Ａ组和Ｂ组在住院７天内再发心绞痛、非致死性心肌梗死，心性死亡分别为３３％与１０％，１７％与０，１１％与０，总的心脏事件发生率为７８％与１５％（Ｐ＜０．０１）。Ｂ组仅３例发生皮下淤斑。结论ＵＡＰ患者急性期用降纤酶治疗有效，安全又方便。更多还原

【Abstract】 Objective To determine the therapeutic effect of defibrase for injection in unstable angina pectoris (UAP). Methods 38 patients with UAP defined as recent onset and prolonged (≥15min) and spontaneous rest pain entered the study. Patients were randomized to receive antianginal agents plus aspirin (100 mg/d) [group A = 18] and antianginal agents plus aspirin defibrase for injection (10 μ add 100ml normal saline once daily venous transfusion [group B = 201]. Results The results showed that that recurrent angina,nonfatal myocardial infarction, cardiac death occurred in 33% vs 10%, 17%vs 0, 11% vs 0 in group A and B, respectively. Total cardiac events occurred in 78% vs 15% in group A and B (P < 0.01 ). Minor bleeding was detected in 3 patients in group B. Conclusion Treatment with defibrase for injection during acute phrase of UAP was efficient, safe and convenient.更多还原