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丙烯腈作业人群的脂质过氧化与抗氧化能力的观察

Effects of Acrylonitrile Exposure on Lipid Peroxidation and Activities of Anti Oxidative Enzymes of Occupational Population

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【作者】 唐钧范卫朱瑞娟应琪马来记陆荣柱

【Author】 TANG Jun 1,FAN Wei 2,ZHU Rui juan 2,et al (1 Dept.of Laboratory Investigation,2 Institute of Occupational Health, Jinshan Hospital,Shanghai Medical University,Shanghai 200540 China)

【机构】 复旦大学医学院金山医院检验科!上海200540复旦大学医学院金山医院职业病防治所!上海200540复旦大学医学院金山医院职业病防?

【摘要】 选取 78名接触丙烯腈 (ACN)的作业人员为接触组 ,并以 73名不接触任何毒物的健康人作为对照 ,测定血清中丙二醛 (MDA)、超氧化物歧化酶 (SOD)和谷胱甘肽过氧化物酶 (GSH -Px)。结果提示 ,接触组的SOD和GSH -Px的活性明显下降 ,而MDA未见升高。经对吸烟、性别进行分层分析 ,也未发现差别有显著性 ,因而本次研究表明ACN能降低机体的抗氧化能力 ,增加职业人群对氧化性应激的易感性

【Abstract】 In order to explore the effects of acrylonitrile exposure on lipid peroxidation and activities of anti oxidative enzymes of occupational population,78 workers occupationally exposed to acrylonitrile were selected as the exposure group,and 73 workers without any exposure to chemical toxicants and other hazards served as the control group.Two groups were statistically similar about sex,age and smoking habit.MDA,and activities of SOD and GSH Px in serum were determined in two groups.The results showed that the activities of SOD and GSH Px of the exposure group were significantly lower than those of the control group,but the level of MDA of the exposure group was higher than that of the control group without statistical significance.In addition,when stratified by sex,smoking habit and duration of exposure,no statistical difference could be found.The results suggest that acrylonitrile exposure can decrease the ability to delete the reactive oxygen species,it is needed to further and comprehensively evaluate the oxidative and anti oxidative status of workers.

【关键词】 丙烯腈脂质过氧化生物监测
【Key words】 AcrylonitrileLipid peroxidationBiomonitor?
  • 【文献出处】 工业卫生与职业病 ,Industrial Health and Occupational Diseases , 编辑部邮箱 ,2001年01期
  • 【分类号】R135.1
  • 【被引频次】10
  • 【下载频次】48
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