【摘要】 目的 :探讨新生儿高间接胆红素血症 (高间胆 )血清中白细胞介素 6 (IL- 6 )及白细胞介素 8(IL- 8)水平变化及其意义。方法 :采用 EL ISA法对住院的高间胆病婴的感染组 (A组 )和非感染组 (B组 )以及对照组进行血清 IL- 6、 IL- 8及胆红素的检测 ,比较各组的胆红素、IL- 6、IL- 8水平 ,黄疸消退前后 IL- 6、IL- 8水平 ,并进行相关因素的分析。结果 :A组总胆红素 (344 .0 3± 74.5 ) μmol/ L,较 B组高 [(2 77.83± 45 .12 ) μm ol/ L],间接胆红素 (间胆 ) (32 2 .9± 72 .12 ) μm ol/ L,较B组高 [(2 5 4.2 9± 44 .8) μmol/ L],A、 B两组 IL- 6分别为 (10 1.6 2± 38.77) ng/ L、 (75 .13± 13.77) ng/ L,均显著高于对照组 [(30 .6 6± 3.17) ng/ L],A、B两组 IL- 8分别为 (190 .0 2± 5 9.0 3) ng/ L 及 (15 0 .5 4± 2 5 .6 2 ) ng/ L,均显著高于对照组 [(10 8.30± 7.37) ng/ L];两组黄疸消退前后的 IL- 6及 IL- 8比较有显著性差异 (P <0 .0 0 1) ,多因素相关分析 ,IL- 6与感染因素密切相关 (P <0 .0 1) ,IL- 8与间胆呈正相关 (P <0 .0 0 1)。结论 :IL- 6及 IL- 8水平高低可作为高间胆病因及免疫自损程度诊断手段之一。更多还原

【Abstract】 Objective:To explore the changes of the serum levels of interleukin-6 (IL-6) and interleukin-8(IL-8) as well as their significance in the neonates with unconjugated hyperbilirubinemia.Methods:The serum IL-6,IL-8 And bilirubin of the hospitalized neonates with unconjugated hyperbilirubinemia and the control group were measured by ELISA . The neonates with hyperbilirubinemia were divided into two groups : the infected group (Group A) and the uninfected group (Group B). The serum levels of bilirubin, IL-6 and IL-8 were compared among the three groups , and the levels of IL-6 and IL-8 before and after subsidence of jaundice were compared with each other.The related factors were analysed.Results: The serum levels of total bilirubin in Group A were (344.03±74.5)μmol/L , higher than those in Group B , which were (277.83±45.12)μmol/L ; the serum levels of unconjugated bilirubin in Group A were (322.9±72.12)μmol/L, also higher than those in Group B , which were (254.29±44.8)μmol/L . The levels of IL-6 in Group A and B were (101.62±38.77)ng/L and(75.13±13.77)ng/L respectively , both of which were much higher than those in the control group (30.66±3.17 ng/L) ; the levels of IL-8 in Group A and B were(190.02±59,03)ng/L and (150.54±25.62)ng/L respectively, both of which were also markedly higher than those in the control group [(108.30±7.37 ng/L)]. There was sigrificant differrnce between the levels of IL-6 and IL-8 before and after subsidence of jaundice in Group A as well as in Group B (P<0.001) . IL-6 was closely related to infective factors (P<0.01), while IL- 8 had positive correlation with unconjugated bilirubin (P<0.001). Conclusion: Determination of the serum levels of IL-6 and IL-8 may be one of the methods in diagnosing the causes of unconjugated hyperbilirubinemia and determining the degrees of immunological self-damage.更多还原