【摘要】 目的 对视网膜色素变性(RP)患者进行F-ERG、P-VEP和EOG三项联合检查,以分析病程和作为建立脉络膜侧枝循环手术的术后疗效跟踪的客观对照指标。方法 采用常规无创伤视觉电生理描记术,测定暗视F-ERG、P-VEP和EOG。结果受检的66名RP患者132只眼中,F-ERG为“熄灭型”的为63.6％,能记录到a-波的仅占1.5％,c-波为3.0％,能记录到b-波与负后电位的分别为30.3％和34.1％,无一例记录到完全正常的F-ERG。完全记录不到P-VEP的占35.1％,刺激中央6°视野能记录到低幅P100波的有49.1％,而刺激周边视野则只有17.5％能记录到P-VEP,且波形多为异常的“W”波。绝大部分RP患者的EOG曲线平坦,光峰与暗谷均消失,Arden比和G比值均明显下降,说明明、暗适应机能已经显著受损。结论 RP患者的F-ERG、P-VEP和EOG都有不同程度的特有改变。更多还原

【Abstract】 Objective To analyze F- ERG,P- VEP and EOG as an index to diagnoze the progress of retinitis pigmentosa(RP) progress as well as to evaluate surgical treatment. Methods Conventional technique of the visual physiological recording was used. Results Scotopic F - ERG of 66 RP patients (132 eyes) was recorded by using the dimmest white flash from the Ganzfeld stimulator. Among them the F - ERG of the overwhelming majority of eyes (63.3 % ) was non - detectable; The a - wave and c - wave were recorded from 1.5% of eyes and 3.0% of eyes respectively; The b - wave and the negative post - potential were recorded from 40 (30.3 % ) and 45 (34.1 % ) eyes respectively. No P - VEP waves was recorded from 35.1 % of the patients with the full - field reverse check - board stimulation. P100 wave was recorded from 49.1% of the eyes when the central 6°visual field was stimulated. The P100 of very low amplitude or "W" - type wave was recorded from 17. 5% of eyes , when the peripherally visual field outside 6°enter was stimulated. In most of the EOG curves, both the light peak and the dark trough disappeared; the Arden ratio and G ratio markedly decreased . Conclusion F - ERG, P - VEP and EOG in patients with RP reveal characteristic changes.更多还原