【摘要】 目的 :为进一步阐明γ-干扰素 (IFN-γ)在原发性肾病综合征 (PNS)发生发展中的作用及检测 IFN-γ的临床诊断价值。方法 :对 32例 PNS患者及 1 0例正常人血清、尿液 IFN- γ的水平进行检测 ,并结合 PNS病理类型及其他临床指标进行分析。结果 :系膜增生性肾炎 (Mes PGN)患者尿 IFN-γ水平显著高于正常对照组 ,而非增生性肾炎组却与对照组差异无显著性 ;其次 ,尿 IFN- γ水平与尿纤维蛋白 (原 )降解产物 (FDP)浓度呈正相关 ;但与血肌酐 (Scr)、血清肌酐清除率(Ccr)、2 4 h尿蛋白定量 (2 4 h UPQ)无相关性。血清 IFN-γ水平各组间差别无统计学意义。结论 :IFN-γ参与增生型 PNS免疫性肾损伤过程 ,并可能通过局部方式起作用 ,尿 IFN- γ检测有可能作为区分增生性肾炎和非增生性肾炎的指标更多还原

【Abstract】 Objective:To assess the effect of interferon γ(IFN γ)on immunologically mediated renal injury in primary nephrotic syndrome (PNS) and its diagnostic significance.Methods:Serum and urine levls of IFN γ were measured with ELISA in 32 patients with PNS and 10 normal controls.The pathologic classification of PNS were made by renal biopsy.Results: Urine level of IFN γ in patients with MesPGN was much higher than that in controls ( P <0.005),while there was no significant difference between cases with non proliferative glomerulonephritis and controls. Urine concentration of IFN γ was correlated positively to that of FDP in petients with PNS ( r =0.38, P <0.05),whereas there was no correlation among urine level of IFN γ and serum creatinine, creatinine clearance rate and 24 hours urine protein quantity.Serum levels of IFN γ showed no differences in all three groups.Conclusion:IFN γ may be involved in renal injury by way of local action in proliferative glomerulonephritis. Urine level of IFN γ could be helpful to differentiation proliferative from non proliferative golmerulonephritis.更多还原