【摘要】 以中国仓鼠肺V79细胞为材料 ,利用兰州近代物理研究所重离子研究装置 (HIRFL)产生的碳离子 ,研究了不同线性能量传递 (LET)的重离子对体外培养细胞的存活效应 ,并与γ射线的结果作了比较。结果表明 ,不同LET碳离子引起细胞失活效应由大到小的顺序依次为 12 5、2 0 0、70 0keV/μm。碳离子表现为无肩区的存活曲线 ,属单靶单击模型 ,γ射线表现为有肩区的存活曲线 ,属多靶单击模型。LET值为 12 5、2 0 0、70 0keV/μm时得到的失活截面分别为 35、12、8μm2 。当细胞存活比率为 0 .1和 0 .37,在LET为 12 5keV/μm时得到相对生物学效应 (RBE)值为1.4 7和 2 .19。更多还原

【Abstract】 In this study , the survival of cultured Chinese V79 hamster cells irradiated with carbon ions with different LETs were investigated. Irradiation was performed at the Heavy Ion Research Facility in Lanzhou (HIRFL). Results were compared with those obtained from the experiments with γ rays and could be concluded as follows: The survival curves for carbon ions showed as straight lines and were fitted to the one-target one -hit model, but for γ rays the curves with shoulders were fitted to the multi-target one-hit model. As the LETs were 125,200 and 700keV/μm for carbon ions, the inactivation cross section 35, 12 and 8μm 2, respectively, which suggested that under the experimental conditions, the lower the LET of carbon ions, the more seriously the irradiation killed cells. In the case of 125keV/μm, the RBEs of carbon ions at the 0.1 amd 0.37 survival levels were 1.47 and 2.19 respectively.更多还原