【摘要】 本文回顾了 T、B淋巴细胞功能与牛白血病发生发展的相关性。阐明了感染 BL V牛 B细胞淋巴瘤细胞除了来源于 B1 a( CD5 +CD1 1 b+)细胞 ,也可来源于 B1 b( CD5 -CD1 1 b+)及常规 B2 ( CD5 - CD1 1 b- )细胞。探讨了 T细胞功能对牛白血病的发生发展的影响 ,指出 IL- 1 2表达下降和 IL- 1 0表达增加可能导致了 B细胞淋巴肉瘤的形成 , 型和 型细胞因子的不平衡引起了 BL V的发展。同时讨论了 B- T细胞的相互作用在 BL V感染时疾病阶段性发展过程中的作用。更多还原

【Abstract】 This review focuses on the relationship between the function of T、B lymphocytes and the pathogenesis of Enzootic Bovine Leukosis. In BLV infection animal, the phenotypes of B cells lymphoma can be derived from B1a(CD5 +CD11b +), B1b(CD5 -CD11b +) and conventional B2(CD5 -CD11b -)cells. Combined with previous findings the data suggests that the decrease of IL 12 and the increase of IL 10 result in the formation of B cell lymphosarcoma, and the imbalance of phenotype Ⅰ and Ⅱ cytokines causes the progression of Bovine Leukemia. Meanwhile, the interaction of B and T cells could contribute to the polyclonal activation and proliferation of B lymphocytes in BLV infectea animals.更多还原