【摘要】 目的为探讨孕妇妊娠期尿碘水平与新生儿脐带血ＴＳＨ的关系，为以尿碘指标进行孕产妇碘营养监测提供合理的解释。方法追踪观察１８０例妊娠期在１２～１８周的孕妇分娩前每月尿碘水平，并用免疫放射法（ＩＲＭＡ）测定其所生新生儿脐带血ＴＳＨ含量，结果孕期尿碘以＜１００、１００～、２００～。３００～、４００μｇ／Ｌ以上分５组，妊娠初期尿碘各组新生儿ＴＳＨ无显著差异（Ｐ＞０．０５），但妊娠全过程平均尿碘水平＜１００μｇ／Ｌ和＞ ３００μｇ／Ｌ的新生儿ＴＳＨ显著高于尿碘水平在 １００－３００μｇ／Ｌ组新生儿（Ｐ＜０．０５）。结论在进行以尿碘为指标的孕产妇碘营养监测时，尿碘的检测最好３次以上才能更好的预防新生儿甲低的发生；同时提示，孕妇妊娠期尿碘并非越高越好，应有个上限标准，本研究认为，妊娠期尿碘水平保持在 １００～３００μｇ／Ｌ为宜。更多还原

【Abstract】 Objective: To explore the relationship between urine iodine in gestation and umbilical cord blood TSH and give a reasonable explanation to the assessment of urine iodine of pregnant for neonate TSH. Methods Observing urine iodine of 180 pregnant women from 12-18 weeks gestation to delivery and umbilical cold blood TSH by IRMA. Results Urine iodine is divided into 5 groups by <100、100～、200～、300～and more than 400μg/L, the cord blood TSH is not related to the urine in early gestation, but the children whose mother’s average urine iodine in gestation were less 100μg/L or more than 300μg/L have a higher TSH. Conclusions In order to reduce neonatal hyperthyroidism, we should collect mother’s urine more than three times in gestation; and the level of urine iodine should have a top limit. This study suggests that it is better between 100-300μg/L.更多还原