【摘要】 目的：了解 GM-CSF受体 (CD116)在急性白血病中的表达及其临床意义。方法：对 114例急性白血病患者进行免疫表型、细胞遗传学分析。结果： CD116在 ALL中无阳性表达，而在 AML中表达率为 42. 4％， CD116在 FAB各亚型间的出现频率存在明显差异， M5中阳性率最高为 83. 3％， M4为 40％， M3、 M2分别为 27. 2％、 15. 0％。 CD116＋ AML中未见特异性染色体异常，但 M5患者 2例出现＋ 8异常，均在 CD116＋组。结论： CD116主要表达在髓系白血病，且与具有单核细胞特征的白血病相关， CD116、 CD4联合染色体＋ 8有利于 M5亚型的诊断。更多还原

【Abstract】 Objectives:To explore the expression of the human granulocyte-macrophage colony stimulating factor receptor(CD16)in acute leukemia and its clinical implications.Methods:Prospectively analyted the relationship between imunophenotyptic featues of the blast cells from 114 patients with acute leukemia.Results:CD116 was no expressed in blasts from ALL,CD116 was expressed in blasts from 42.4％ of AML,incidence of CD116 expression in each FAB subtype was also different,the highest expression was seen in M5(83.3％ ),M4 expressed CD116 in 40％ of leukemic cells,M3 in 27.2％ and M2 in 15.0％ .There are no specific chromsome karyotype abnormal in CD116 positive AML.However,two patients had＋ 8 karyotpe in CD 116 positive M5.Conclusion:CD116 and CD4 combing＋ 8 might be important to diagnose M6.更多还原