【摘要】 内毒素诱生多种介质的参与是脓毒症发病的重要环节，其中肿瘤坏死因子－α（ＴＮＦ－α）可能在内毒素诱发的炎症介质“瀑布效应”中起重要作用。本文针对ＴＮＦ－α合成的５个作用环节，概述了ＴＮＦ－α拮抗剂防治脓毒症的研究现状。更多还原

【Abstract】 Tumour necrosis factor (TNF) is an essential mediator in the pathogenesis of septic shock associated with lipopolysaccharide (LPS) from gram negative organisms. For these reasons, there was considerable expectation that modulation of the TNF response would be of benefit to patients suffering the consequences of severe infection. In this review, the treatment approach in TNF mediated sepsis will be considered at five steps in the TNF biosynthetic pathway.更多还原