【摘要】 目的 :探讨多药耐药糖蛋白 (P- gp)的发生规律。方法 :以 MDR1 基因、P- gp和 blc- 2蛋白表达的测定为主要实验室指标 ,根据 93例初治急性非淋巴细胞白血病患者的临床资料的结果 ,分析 P- gp发生规律及其与临床疗效之间的关系。结果 :年龄 >6 0岁、骨髓涂片中两系以上的病态造血以及巨核细胞不减少与初诊时 P- gp的表达水平呈正相关。结论 :上述临床特征易诱发继发性 P- gp过度表达。MEA方案以及高剂量化疗诱发继发性 P- gp表达的作用弱于 DA和 HA方案及非高剂量化疗。更多还原

【Abstract】 Objective:To investigate into the generation rule of P gp.Methods:The expression of P gp and bcl 2 protein ,expression of MDR 1 gene were taken as targets and according the clinical data from 93 patients suffering from ANLL,the generation rule of P gp was analyzed.Results:Patients of over 60 years,having morphological dysplasia of more than 2 cell lines and normal megakaryocyte number in bone marrow had relationship with primary overexpression of P gp,and a tendency of secondary overexpression of P gp can be also abserved.Conclusion:Chemotherapy with MEA scheme and high intensive chemotherapy had a lower effect of inducing secondary overexpression of P gp than HA and DA scheme and non high intensive chemotherapy.更多还原