【摘要】 大量研究证实血红素蛋白或NAD(P)H氧化酶是缺氧感受器，并由此引起一系列缺氧的信号传导过程，包括cAMP、Ca2＋、NO、CO、cGMP等信使分子的参与，最终激活缺氧诱导因子-1（HIF-1）使机体产生缺氧反应。还有人认为线粒体参与这一过程，而且可能是缺氧感受器，此外，HIF-1和缺氧反应基因（HRG）的转录调控机制也参与了缺氧过程。更多还原

【Abstract】 ：Evidence has accumulated that the O2 sensors have been the identity as flavoheme protein or NAD(P)H oxidase which invokes a series sensory transduction. Among the candidates for O2 sensor are camp, Ca2+, NO, CO, camp mitochondria cytochrome aa3 complex which activited HIF-1 and regulation of HRG gene express by HIF-1 has also been investigated.更多还原