【摘要】 目的 :探讨神经瘤的形成机制和致痛机理及周围神经与带蒂骨骼肌桥接吻合后神经瘤的生长情况。方法 :Wistar大白鼠 4 0只 ,随机分为实验组与对照组 ,两组均将左侧坐骨神经在适当水平切断 ,远端神经切除 ,实验组近端神经分为两束 ,用带蒂骨骼肌桥接两个神经断端 ,对照组近端神经置于原位。饲养 16周进行检测。结果 :实验组再生的神经纤维顺利通过吻合口长入骨骼肌肌桥内 ,并在肌桥的肌束内生长 ,分布于肌纤维之间 ,未见神经瘤形成 ;对照组均有典型的神经瘤形成。结论 :采用带蒂骨骼肌桥接断裂的周围神经近端后再生的神经纤维能顺利通过吻合 ,并沿肌外膜内和肌束之间生长 ,可防止神经瘤的形成。更多还原

【Abstract】 Objective:To probe into the mechanism of the formation of neuroma and stump pain,and the development of nerve fibres after the proximal ends of peripheral nerve were bridged by pedicled skeletal muscle.Methods:Forty Wister white rats were randomly divided into experimental group and control group.The left sciatic nerves of all the rats were transected at the same level,and the distal parts of nerves were cut off. The proximal end of the transected sciatic nerve in th experimental group was longitudinally divided into two parts,and the two ends were bridged by pedicled skeletal muscle.The proximal ends of sciatic nerves were left in situ.The sciatic nerves were detected after 16 weeks.Results:In experimental group,the regenerated nerve fibres grew into skeletal muscle bridge via anastomosis and distributed among the skeletal fascicle,and there was no formation of neuroma.Conclusion:The pedicled skeletal muscle bridging of the proximal ends of the amputated peripheral nerves may prevent the formation of neuroma. [更多还原