【摘要】 目的　探讨人群心脑血管病发病率、死亡率与不同脉压水平的流行病学特征。方法　采用 1997年北京城市、农村自然人群高血压普查资料 ,共 2 970 7例 ,平均随访 2 .1年。对在随访期间发生的心脑血管病事件进行登记 ,计算不同血压水平的脉压均值、标准差 ,心脑血管病事件标化发病率和多因素 Cox回归模型。结果　 1在血压正常人群和高血压人群中平均收缩压水平随着脉压的增高而增高 ;2血压正常人群脉压在 45 mm Hg时 ,脑血管病和冠心病标化发病率和死亡率最高 ;高血压人群脉压越高脑血管病和冠心病发病率和死亡率越高 ;3脉压每增加 10 m m Hg,男性高血压人群死于脑血管病的危险增加 1.18倍。结论　脉压是一个非常强的预测指标 (在我国 ,尤其是脑血管病的发病率 )。更多还原

【Abstract】 Objective To explore the prevalence of pulse pressure and incidence and mortality of cardiovascular disease (CVD) in normotensive and hypertensive population.Methods A cohort study was carried out in Beijing natural population,totally 29 707 hypertensive subjects in 1997 for 2.1 years follow up.All new CVD events and death due to CVD occurring within the follow up period were registered.All event rates were age standardized.The mean and standard deviation were calculated on pulse pressure.The different causes of mortality were tested using a multivariate Cox regression.Results ①Systolic blood pressure increased with pule pressure in normotensive and hypertensive population.②Incidence and mortality to CVD and stroke were highest when pulse pressure (PP) was 45mmHg in normotensive population,and incidence and mortality to CVD and stroke increased with pulse pressure in hypertensive population.③A 10mmHg increase of PP would subsequently increas the risk of stroke mortality by 18% in male.Conclusions High pulse pressure is an main risk factor for CVD;pulse pressure is an independent predictor of CVD in both normotensive and hypertensive population.更多还原