【摘要】 对不同年龄雄性小鼠进行研究 ,经七周有氧 (游泳 )训练 ,较系统的观察有氧运动训练对增龄小鼠的影响 ,研究认为 :1)从 3月到 12月龄 ,心肌肌动球蛋白ATPase、肌球蛋白ATPase活性逐渐下降 ,增龄引起心肌收缩蛋白ATPase活性的降低。 2 ) 3月到 12月龄 ,心肌SRCa2 + -ATPase活性也逐渐下降。 3) 8周游泳训练缓解了心肌收缩蛋白ATPase活性增龄性下降速度 ,改善了心肌肌浆网钙摄取功能的增龄性降低趋势。 4)从心肌收缩蛋白及肌浆网ATPase变化看 ,老年期对一次急性运动的反应比年轻者更敏感 ,而游泳训练则能降低各年龄段对运动刺激的反应敏感性。 5 ) 8月龄 ,游泳训练对心肌收缩蛋白ATPase活性产生明显改善作用 ,而在 12月龄游泳训练对SRCa2 + -ATPase活性的影响非常显著。在老年期心脏仍保持一定的可塑性而对运动训练产生适应。更多还原

【Abstract】 The male mice of different age were studied during 7 weeks of aerobic training (swimming) to observe systemically effects of the training on them. The results were as follows: 1. In mice of 3 months to 12 months of age the myocardial actomyosin ATPase activity and myosin ATPase activity declined gradually. That is to say, the myocardial contractile protein ATPase activity decreased with aging. 2. In mice of the above age, the myocardial SR Ca2 +-ATPase activity also declined. 3. The swimming training for 8 weeks reduced the speed of decrease with aging in myocardial contractile protein ATPase and improved the tendency of decrease with aging in calcium uptake function of myocardial sacoplasmic reticulum (SR). 4. In terms of changes in myocardial contractile protein and SR ATPase, the old mice responded to an acute exercise more sensitively than the young mice, but swimming training could relieve this tendency in spite of their age. 5. The swimming training produced apparent improvement of myocardial contractile protein ATPase activity in mice of 8 months old. There was a significant increase in SR Ca2 +-ATPase activity of 12 months old mice. During the old age their hearts still retained plasticity, which produced adaptation to exercise training.更多还原