【摘要】 用 3种双烷氧基环乙烷对红霉素肟的肟羟基加以保护 ,实验发现 ,1,1-二异丙氧基环己烷和 1,1-二乙氧基环己烷的效果比较好 ,工艺条件为二氯甲烷作溶剂 ,盐酸吡啶作催化剂 ,反应温度 4 0℃ ,反应时间前者 1h,后者 7h更多还原

【Abstract】 The reaction of dialkyloxy cyclohexane with erythromycin oxime is studied. Experimental results show that 1,1 diisopropyloxy cyclohexenane (Ⅰ) and 1,1 diethoxy cyclohexenane (Ⅱ) can be considered as protective reagents for hydroxyls of erythromycin oximes. The optimal reaction conditions are as follows: reaction solvent: dichloromethane; catalyst: pyridine hydrochloride; reaction temperature: 40 ℃: reaction time: (Ⅰ) 1 h, (Ⅱ) 7 h.更多还原