【摘要】 目的：探讨各种类型肝病患者血清Ⅳ型胶原水平的变化及其意义。方法：采用双抗体夹心ELISA法检测184例各型肝病患者血清Ⅳ型胶原水平，并与30例健康对照组比较。结果：慢性肝炎中度、慢性肝炎重度、慢性重症肝炎加肝硬化及肝癌组患者血清Ⅳ型胶原水平与对照组及急性肝炎组比较差异均有显著性(Ｐ＜0.01)。结论：血清Ⅳ型胶原测定对慢性肝病肝纤维化严重程度和预后判断有重要临床意义。更多还原

【Abstract】 Objective:To explore the change of serum col lagen Ⅳ level in patients with different liver diseases.Methods:ELISA was used to detect the serum collagen Ⅳ level in 184 patients with liver diseases and 30 healthy controls.Results:Serum collagen Ⅳ level was elevated in the groups of chroni c hepatitis(moderate type,severe type),chronic severe hepatitis and liver cirrhosis,and hepatocellular carcinoma.There was significant difference betweenthese groups and healthy control or acute hepatitis group(Ｐ＜0.01).Conclusions:The detection of serum collagen Ⅳ is important for asse ssment of the grade of hepatic fibrosis and prognosis of chronic hepatitis.更多还原