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萌动激活赤灵芝孢子粉对小鼠脾细胞IL-2的分泌和脾淋巴细胞转化增殖的影响

Effects of Actively Germinating Ganoderma spore on the secretion of IL-2 and the Transformation and Proliferation of mouse splenocyte

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【作者】 陈小君; 冯翠萍; 梅承恩; 刘昕; 钟南强;

【Author】 CHEN Xiao-jun,FENG Cui-ping,MEI Cheng-en (Cancer Institute,Sun Yat-sen University of Medical Sciences,Guangzhou 510060) LIU Xin,CHUNG Chee-keung (School of Life Sciences,Sun Yat-sen University,Guangzhou 510275)

【机构】 中山医科大学肿瘤研究所!广州510060; 中山大学生命科学学院!广州510275;

【摘要】 目的 :探讨萌动激活赤灵芝孢子粉对小鼠脾细胞IL 2分泌和脾淋巴细胞转化增殖的影响。方法 :实验小鼠随机分成实验组 (低剂量组 4 g/kg/d :高剂量组 :8g/kg/d)和对照组 (与实验组用同体积的生理盐水 ) ,连续用药 1 0天。用3H—TdR掺入法进行检测。结果 :与对照组相比萌动激活赤灵芝孢子粉对小鼠脾细胞IL 2分泌有明显促进作用并能明显提高小鼠脾淋巴细胞转化增殖 ,并有一定的量效关系。结论 :萌动激活赤灵芝孢子粉对小鼠免疫功能有明显的促进作用 ,这可能与其促进细胞因子的分泌和淋巴细胞转化增殖有关。

【Abstract】 To explore the action of actively germinating ganoderma spore on the secretion of IL-2 and the transformation and proliferation of mouse splenocyte.Methods:3H-TdR incorporation scintillation count assays. Results: Compared with the control,the actively germinating ganoderma spore not only dramatically increased the secretion of IL-2 but also enhanced the transformation and proliferation of mouse splenocyte with dose manner. The actively germinating ganoderma spore possesses obviously immuno-promoting effect on mouse immune system and this effect might be related with the secretion of cytokines and the proliferation and transformation of lymphocyte

  • 【文献出处】 氨基酸和生物资源 ,Amino Acids & Biotic Resources , 编辑部邮箱 ,2001年01期
  • 【分类号】R285
  • 【被引频次】40
  • 【下载频次】243
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