【摘要】 目的：探讨结肠直肠癌组织ＣＥＡ的表达情况，分析组织ＣＥＡ与结肠直肠癌临床生物学特性的关系及其对预后的影响。方法：用免疫组化 ＬＳＡＢ法测定 １８９例结肠直肠癌组织 ＣＥＡ的表达强度，并用 ＳＰＳＳ ６． ０软件在计算机上统计，分析其与结肠直肠癌临床生物学各项指标的关系，包括肿瘤大小、病理类型、病理分化、浸润深度、淋巴结转移、术前肝转移、术后转移复发、疾病分期、生存期及术前血ＣＥＡ。结果：ＣＥＡ在结肠直肠正常粘膜和癌组织的表达有明显的差异（Ｐ＜０．００１）；癌组织ＣＥＡ是反映结肠直肠癌临床生物学特性的指标，与肿瘤病理分化、浸润深度、淋巴结转移、术前血ＣＥＡ水平、术后转移复发及生存期密切相关（Ｐ＜０．０５）：肿瘤分化越差，癌组织ＣＥＡ表达越强；癌组织ＣＥＡ表达强者较表达弱者具有更深的肠壁浸润、更高的淋巴结转移率、术后肿瘤转移复发率、更晚的分期以及更短的生存期；癌组织ＣＥＡ呈强阳性表达者其术前血ＣＥＡ阳性率和水平均较高；术前血ＣＥＡ阳性且癌组织ＣＥＡ呈强阳性表达者术后转移复发率最高（５０％），生存期最短（２１个月）。结论：正常结肠直肠粘膜也可表达ＣＥＡ，但强度与阳性率与癌组织有明显差异；癌组织ＣＥＡ是反映结肠直肠癌临床?更多还原

【Abstract】 Objective: The aim of this study was to investigate the distribution of carcinoembryonic antigen (CEA) in colorectal cancerous tissue and to evaluate its clinicobiological significance, especially its prognostic value. Methods: Distribution of tissue CEA in 189 patients with colorectal cancer were detected with immunohistochemical method, and its relationship with many clinicopathological parameters was analyzed with SPSS software. Results: CEA distributed in both tumor tissue and normal mucosa but there was a significant difference between them. Staining positive rate of CEA in tumor tissue was 96. 3%, with 52. 4% strong and 36. 5% moderate. While in normal mucosa it was 17. 4%, with 16. 2% weak and 1. 2% moderate. There was a close relationship between tissue CEA and many clinicopathological parameters, such as differentiation, invasion depth, metastasis to regional lymph node, preoperative serum CEA level, postoperative tumor recurrence, metastasis, and postoperative survive. Conclusions: CEA overexpression in colorectal cancer tissue. Tissue CEA is a good prognostic indicator for colorectal cancer reflecting its clinicobiological features. Combining tissue CEA with serum CEA level should be better for predicting prognosis, and patient with both elevated preoperative serum CEA level and strong expression of CEA in tumor tissue indicates the worst prognosis.更多还原