【摘要】 目的 :观察α -淀粉酶对致龋细菌粘附量的影响 ,探讨α -淀粉酶与龋病的相关性。方法 :采用不同浓度α-淀粉酶及全唾液作为实验性获膜成分 ,观察经放射性同位素H -TDR标记了的变形链球菌对羟基磷灰石的粘附情况。结果 :α -淀粉酶组与对照组相比 ,不同浓度的α -淀粉酶均能明显抑制变形链球菌对羟基磷灰石的粘附 (P <0 0 5 ) ,而且其作用随浓度增加而增强 (P <0 0 5 ) ;α -淀粉酶组与无龋正常人全唾液组相比 ,均可抑制变形链球菌对羟基磷灰石的粘附 ,但 <2 0 0mg/ml浓度的α -淀粉酶组与全唾液组相比作用较弱 (P <0 0 5 )。 结论 :α -淀粉酶有可能抑制龋病的发生。更多还原

【Abstract】 Objective\ The relationship between the α- amylase and the adherence of S.mutans to hydroxyapatite in vitro.Methods\ The adherence of S.mutans marked with 3H-TDR to hydroxyapatite covered by α-amylase was observed in varied concentrations,and whole saliva as experimental pellicles respectively.Results\ α-amylase significantly inhibited the adherence of S.mutans to hydroxyapatite,and that was heightened with the increased concentrations. The inhibition of α-amylase against the adherence of S.mutans to hydroxyapatite was similar to that of caries-free adults’ whole saliva. Conclusions\ α-amylase may inhibit the occurrence of dental caries .更多还原