【摘要】 目的 :对双轮牌新生代酒的毒性和致突变性进行初步安全性评价。方法 :依照食品安全性毒理学评价程序和方法进行试验设计和检测。结果 :雌、雄性小鼠急性经口半数致死量 (LD50 )均大于 2 0 .0 0g/Kg体重 ,急性毒性半数致死量 (LD50 )毒性分级属实际无毒 ;小鼠嗜多染红细胞微核试验、小鼠精子畸形试验和Ames试验结果均为阴性 ,未见致突变性 ;30天喂养试验 ,实验动物生长发育良好 ,血液学检查、生化学检查、主要脏器脏体比及组织学检查结果与对照组相比 ,差异均无显著性 (P >0 .0 5 )。结论 :双轮牌新生代酒作为食品是安全的。更多还原

【Abstract】 In order to assess safety of Xinshengdai wine, Shuanglun Brand, its toxicity and mutation were detected according to assessment procedure and method of toxicology for food safety. The results indicated that LD 50 to male and female mice was all more than 20.00g/kg weight. It was classified as no toxicity. Red blood cell micronucleus test of mice, malformation test of mice sperm and Ames test were negative. No mutation was observed. Mice developed well after feeding 30 days. There were no significant differences between experiment group and control group in blood examination, biochemical detection, main organ check and histological examination (P>0.05). The results proved that Xinshengdai wine, Shuanglun Brand was safe as food.更多还原