【摘要】 目的 :探讨冬凌草甲素的抗突变作用。方法 :采用Ames试验及小鼠骨髓嗜多染红细胞 (PCE)微核试验。结果 :冬凌草甲素在未加S9条件下 ,对TA98及TA10 0回复突变具有明显的抑制作用 ,其最高抑制率分别达 89 1%及 80 2 % ;对由环磷酰胺(CP)诱导的小鼠骨髓PCE微核发生率也有显著的拮抗作用 (P <0 .0 1)。结论 :冬凌草甲素在本实验条件下具有抗突变活性更多还原

【Abstract】 Purpose: To study the antimutagenicity of Oridonin Methods: Ames test and micronucleus assay of polychromatic erythrocytes in mice bone marrow were used. Results: Oridonin could evidently inhibit the reverse mutation on Salmonella typhimuriun strains TA98 and TA100 without S9mix. The rates of maximum inhibition were 89.1% and 80.2% respectively. In addition, Oridonin could significantly reduce micronucleus frequencies induced by cyclophosphamide (P<0.01). Conclusion: Oridonin has significant antimutagenic effect.更多还原