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白细胞介素—1等细胞因子与肺阴虚证本质的相关性研究

Study on Correlatively of Interleukin - 1 and Other Cellular Factors with Essence of Deficiency of the Lung-yin

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【作者】 申维玺孙燕张叔人余桂清

【Author】 Shen Weixi, Sun Yan, Zhang Shuren, et al. Guangzhou City Hospital of Tumor, Guangzhou 510095.

【机构】 广州市肿瘤医院内科中国医学科学院中国协和医科大学肿瘤医院中国中医研究院广安门医院 广东省广州市横枝岗路78号 510095

【摘要】 应用免疫组化方法研究了白细胞介素—1(IL—1β)、白细胞介素—6(IL—6)、肿瘤坏死因子(TNFα)与肺阴虚证的关系。结果表明,巨噬细胞等非瘤细胞中IL—1β、TNFα表达水平与肺阴虚证有关,肺阴虚证组非瘤细胞中IL—1β、TNFα表达水平高于正常对照组和病人对照组;非瘤细胞中IL—1β/IL—6比值、TNFα/IL—6比值与肺阴虚证有密切关系,肺阴虚证组非瘤细胞中IL—1β/IL—6、TNFα/IL—6比值高于正常对照组和病人对照组。根据中医证本质标准和本文结果等综合分析,我们初步认为,IL—1和TNF等细胞因子是肺阴虚证的本质。

【Abstract】 The relations between of interleukin - 1β (IL - 1β), interleukin - 6 (IL- 6), tumor necrosis factor (TNFa) and lung yin - deficiency syndrome were studied by means of immunohistachemical method. Results indicated that expression levels of IL - 1β and TNFα in macrophages and other non - tumor cells were correlated with lung yin -deficiency syndrome, expression levels of IL -Iβ and TNFα in non - tumor cells of lung yin-deficiency syndrome group were higher than those of normal control group and patient control group; the IL- 1β/IL - 6 ratio and TNFα/IL -6 ratio in non -tumor cells were closely related with lung yin - deficiency syndrome, IL- 1β/IL - 6 ratio and TNFα/IL -6 ratio in non-tumor cells of lung yin-deficiency group were higher those of the normal control group and the patient control group. The authors hold that IL -1β and TNFα cellular factors are essence of yin-deficiency.

  • 【文献出处】 中医杂志 ,Journal of Traditional Chinese Medicine , 编辑部邮箱 ,2000年07期
  • 【分类号】R228
  • 【被引频次】54
  • 【下载频次】333
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