【摘要】 目的 :观察不同剂量的川芎嗪加入到 4 2 5%透析液中对腹膜超滤功能的影响。方法 :4 0只SD大鼠随机分为 4组 ,除对照组外 ,其余 3组每日分别腹腔注射 2 5ml 4 .2 5%透析液 (HGC) ,HGC加低剂量( 4 0mg/L)川芎嗪 (HGL)和HGC加高剂量 ( 160mg/L)川芎嗪 (HGH)。至第 4 5天结束时 ,以131I标记的白蛋白溶于 2 5ml 4 2 5%透析液注入腹腔 ,进行腹膜功能试验。结果 :与对照组比较 ,各透析组 4h排液量显著降低 ,而HGL组排液量显著高于HGC组和HGH组。各透析组腹透液重吸收和直接淋巴吸收均显著高于对照组 ,各透析组之间比较则差异无显著性。HGL组透析液与血浆尿素浓度之比 (D/Purea)与HGC组比较无显著性差异 ,但透出液中葡萄糖浓度与未使用过的 4 2 5%透析液中葡萄糖浓度之比 (D/D0 )及尿素清除率(Curea)显著高于HGC组和HGH组 ;HGH组D/Purea显著增加。结论 :低剂量川芎嗪加入到腹透液中可减少高渗透析液引起的腹膜功能损伤 ,增加超滤及透析效能 ,高剂量川芎嗪则可引起腹膜通透性增高。更多还原

【Abstract】 To study the effect of ligustrazine on peritoneal transport in various dosages. Methods: Forty SD rats received intraperitoneal injection of 25 ml 4.25% glucose dialysis solution (GDS) or GDS plus 40 mg/L ligustrazine (GDS-LL) or GDS plus 160 mg/L ligustrazine (GDS-HL) daily, for 45 days. Then a 4-hour dwell study was performed in each rat to evaluate the peritoneal transportation. Results: The drainage volume at 4 hours was significantly lower in all the dialysis groups as compared to the control group, especially in the GDS-HL group. However, drainage volume was significantly higher in the GDS-LL group as compared to the GDS and GGS-HL groups. There were no significant differences in the peritoneal fluid absorption rate among the 3 dialysis groups. The fluid absorption rate and the direct lymphatic absorption rate were all significantly higher in the 3 dialysis groups as compared to the control group. In the GDS-LL group, the ratio of urea level in dialysis solution and in plasma (D/Purea) was not different in comparing with that in the GDS group, but the ratio of glucose concentration in dialysis solution and that in unused dialysis solution (D/D 0), and urea clearance were significantly higher than those in the GDS group and the GDS-HL group. D/Purea increased in the GDS-HL group significantly. Conclusion: Low dose of ligustrazine adding to the dialysis solution could reduce the peritoneal damage caused by the hypertonic dialysis solution, increase the ultrafiltration function and dialysis function of peritoneum. However, high dose of ligustrazine does not display any beneficial effect, it increases the permeability of peritoneum.更多还原