【摘要】 目的:探讨桦树皮抗肿瘤作用及其作用机制。方法:应用桦树皮提取物（EBB）口服观察其对小鼠不同肿瘤的抑制作用。免疫功能检测的方法为胸腺（脾）指数的测定及脾细胞对ConA刺激的反应性和NK细胞活性的测定。结果:EBB抑制小鼠S₁₈₀、B₁₆黑色素瘤和 Lewis肺癌的生长;并能延长S₁₈₀和EAS腹水癌小鼠生存期;EBB还可使荷瘤小鼠胸腺（脾）指数增大及增强荷瘤鼠脾细胞对ConA刺激的反应性和NK细胞的活性。结论:桦树皮提取物具有抑制肿瘤细胞的生长、增强机体免疫功能的作用。更多还原

【Abstract】 Objective: To study the antitumor effect of extract of birch bark (EBB) and its influnce to the immune function of the tumor-bearing mice. Method: EBB was administered orally and the tumor inhibiting effects were observed in tumor-bearing mice.Experiment of the immune function are to examine thymocytes (spleen) index, reaction of spleen to ConA and activiy of NK cell. Results: EBB showed antitumor effect in vivo to B16,S180 and Lewis lung cancer in mice.EBB can significantly prolong survival period of bearing tumor mice.EBB can enhance thymocytes and spleen index in C57 BL/6 mice.EBB can enhance splenic lymphocytes translate and activit of NK cell (P<0.05). Conclusion: EBB have antitumor effect and enhance immune function in bearing tumor mice.更多还原