【摘要】 目的 :通过对凝胶剂经皮渗透速率的比较 ,优化二乙胺水杨酸凝胶剂处方。方法 :用 3种不同浓度异丙醇作促渗剂 ,制备凝胶。采用Franz扩散池进行小鼠离体皮肤体外渗透试验。结果 :药物经皮渗透符合零级动力学过程 ,不同浓度异丙醇促渗效果为 :15 %异丙醇 >10 %异丙醇 >5 %异丙醇。结论 :经皮渗透试验筛选处方是可行的。更多还原

【Abstract】 OBJECTIVES: To optimize the formulation of diethylamine salicylate gel by comparative study on transdermal osmotic rate.METHODS: 3 diethylamine salicylate gels were prepared using 2 propanol as osmotic enhancer in different concentration and Fanz diffusion cells were adopted in the transdermal osmotic test of isolated mouse skin. RESULTS: The transdermal osmotic process fitted to a zero order kinetic mechanism. The osmotic enhencer effect of 2 propanol was listed below: 15%> 10%>5%. CONCLUSIONS: The method adopted for screening the formulation of the gels is feasible.更多还原