【Abstract】 Objective: To study the mechanism of acupuncture in treating simple obesity. Methods: Central nerve push pull perfusion and biochemical technique were used to observe the effect of acupuncture on the obese parameters, changes of monoamine transmitters and activity of ATPase in the lateral hypothalamic area (LHA) of obese rats. Results: Noradrenaline (NA) level in LHA of obese rats was higher but serotonin (5 HT) level and ATPase activity were lower than those in normal rats. After acupuncture treatment, in the same time of reducing body weight, NA level in LHA of rats was reduced, and 5 HT level and ATPase activity in it were increased.( P <0.05 and P < 0.01). Conclusion:The effective regulation on LHA of obese rats is possibly one of the key factors in anti obesity effect of acupuncture.更多还原