【摘要】 目的 :研究补阳还五汤抗脑缺血后迟发性神经元坏死 (DNN)作用与一氧化氮 (NO)和一氧化氮合酶(NOS)的关系。方法 :采用沙土鼠双侧颈总动脉夹闭脑缺血再灌注模型 ,于再灌注后 48小时取前脑皮质测定NO和 NOS。结果 :缺血再灌注后 48小时脑组织 NO含量和 NOS活性降低。腹腔注射补阳还五汤可增加缺血再灌注 48小时后脑组织 NO含量 ,提高 NOS活性。结论 :脑缺血后 DNN与脑内 NO的生成减少有一定的关系 ,补阳还五汤可能通过调节脑组织 NO的生成而发挥抗脑缺血的作用更多还原

【Abstract】 Objective:To study the action of Buyang Huanwu decoction(BYHWD,补阳还五汤) on delayed neuronal necrosis (DNN) after cerebral ischemia and the relationship between nitric oxide(NO) and nitric oxide synthetase (NOS).Methods:Cerebral reperfusion models were built by clamping bilateral carotid arteries of gerbils NO and NOS of antecerebral cortex were detected 48 hours later.Results:About 48 hours after cerebral reperfusion,NO content and NOS activity were decreased.Injection of BYHWD into belly could increase NO content and NOS activity.Conclusions:DNN after cerebral ischemia is related to the decrease of NO.BYHWD may play an antiischemic role through modulating the generation of NO.更多还原