【摘要】 目的 :观察葛根素治疗不稳定型心绞痛 (U AP)的临床疗效及对 UAP患者凝血纤溶活性和内皮功能的影响。方法 :70例 UAP患者随机分为葛根素治疗组 (A组 ) 4 0例和对照组 (B组 ) 30例 ,2组均予心绞痛常规治疗 ,A组加用葛根素注射液静滴。分别观察治疗 2 0日前后心绞痛疗效 ,并检测血浆中凝血纤溶活性指标包括抗凝血酶 (AT )、纤溶酶活组织型纤溶酶原激活剂活性 (t PA:a)、纤溶酶原激活物抑制剂活性 (PAI:a)、内皮素 (ET)及一氧化氮 (NO)的变化。结果 :A组治疗心绞痛疗效的总有效率 87.5 %明显优于 B组 6 0 .0 % (P<0 .0 5 ) ;经葛根素治疗后凝血纤溶活性及内皮素含量均明显改善 ,与 B组比较差异显著 (P<0 .0 5和 P<0 .0 1)。结论 :葛根素治疗不稳定型心绞痛疗效肯定 ,且可改善凝血纤溶系统活性 ,调节内皮舒缩功能。更多还原

【Abstract】 Objective:To observe the effect of puerarin on unstable angina pectoris (UAP) and its coagulant,fibrinolytic and endothelial function.Methods:70 UAP patients were randomly divided into two groups:puerarin treatment group (group A) and routine treatment group (group B).All treatment effect rate of angina was recorded;the antithrombin Ⅲ(ATⅢ),plasminogen activator inhibitor activity (PAI:a),plasmin activity( PL:a ),tissue plasminogen activator activity (tPA:a),endothelin(ET) and nitric oxide (NO) were measured before and after twenty days treatment in two groups.Results:①The total effective rate of antiangina pectoris was significantly higher in group A(87 5%) than that in group B (60 0%,P<0 05).②All indexes of coagulant,fibrinolytic and endothelin level were more improved in group A than those in group B (P<0 05 and P<0 01).Conclusions:Puerarin is an effective drug for UAP,and obviously improves coagulant and fibrinolytic activity.It also can regulate the relaxervasodilator function of endothelial cells.更多还原