【摘要】 检测急、慢性乙型肝炎患者血清IL-10和IFN-γ水平,探讨乙型肝炎慢性化的机理。方法:用双抗夹心ELISA法定量检测25例急性乙肝,35例慢性乙肝和30例正常人血清IL-10和IFN-γ水平。结果:慢性乙肝患者血清IL-10浓度明显高于急性乙肝患者(P<0.01),且高于正常对照组(P<0.01)。而慢性乙肝组患者血清IFN-γ浓度明显低于急性乙肝组(P<0.01),两组的血清IFN-γ浓度均明显高于正常对照组(P<0.01)。慢性乙肝患者血清IFN-γ浓度与ALT有相关性。结论:慢性乙肝患者IL-10水平增高,限制了IFN-γ合成,削弱了其对HBV清除作用,可能是乙型肝炎慢性化机理之一;慢性乙肝患者血清IFN-γ浓度与ALT有相关性。更多还原

【Abstract】 To determine the serum IL-10 and IFN-γ levels in patients with acute and chronic hepatitis B andto study chronicity mechanism of hepatitis B. Method :The serum IL-10 and IFN-γ levels in 25 patients with acute hepatitis B. 35 patients with chronic hepatitis B and 30 health human were determined by ELISA. Results: The serum IL-10 level in patients with chronic hepatitis was obviously higher than that of acute hepatitis B and control (P<0. 01). While serum IFN-γ level in patients with chronic hepatitis B was obviously lower than that of acute hepatitis B (P<0. 01). Serum IFN-γ levels in two groups all were obviously higher than that of control group (P<0. 01). The IFN-γ level in serum of patients with chronic hepatitis B was relate to ALT. Conclusion: That the IL-10 level in serum of patients with chronic hepatitis B was increased inhibited the production of IFN’-T in serum and impaired it’s effect of clearing HBV. This could be one of chronicity mechanism of HBV infection.更多还原