【摘要】 目的:探讨妊娠期肝病对围产儿的影响。方法:测定47例正常孕妇和637例妊娠期肝病孕妇所生648名新生儿的Apgar分值和出生时体重。结果:与病毒性肝炎孕妇相比,对照组和乙肝病毒携带产妇所生新生儿Apgar分值和出生时体重均有显著差异(均P<0.01),而ICP孕妇所生新生儿Apgar分值和出生时体重则均无显著差异(均P>0.05)。肝功能异常孕妇血清总胆红素,直接胆红素和总胆汁酸与新生儿Apgar分值和出生时体重呈非常显著和显著负相关(均P<0.01,均P<0.05),而血清谷丙转氨酶、谷草转氨酶和碱性磷酸酶与新生儿Apgar评分和出生时体重却无显著相关关系(均P>0.05)。血清白蛋白和总蛋白水平与1分钟Apgar评分分别有非常显著和显著正相关(P<0.01,P<0.05)。结论:孕妇病毒性肝炎与ICP对围产儿生长发育和出生时状态影响相似。肝功能异常孕妇血清胆红素和胆汁酸水平可能与围产儿生长发育和出生时状态有关,而血清白蛋白水平可能与新生儿出生时状态有关。更多还原

【Abstract】 Aim; To explore the influence of hepatic disease in pregnancy on the newborn. Methods: Apgar score and birth weight were measured in 648 newborns born to mothers with hepatic diseases and 47 newborin born to healthy mothers. Results: Apgar score and birth weight of newborns born to mothers with viral hepatic were significantly lower than those of newbrons bron to healthy mothers and HBV carriers(all P<0. 01). No significant difference in Apgar score and birth weight were found between newborns born to mothers with viral hepatitis and those born to mothers with in-trahepatic cholestasis of pregnancy (ICP) (all P<0. 05). Maternal serum levels of bilirubin were very significantly and significantly related negatively with Apgar score and birth weight (P<0. 01, P<0. 05). .In contrast, mateenal serum levels of albumin was significantly related positively with 1-minute Apgar score (P<0. 05). Conclusion: Effect of viral hepatitis in pregnancy is similar to that of ICP on the newborn. Maternal disorder of bilirubin metabolism and albumin may influence fetus growth and birth condition.更多还原